Why Don't You Take Spiro Anymore? (You Mentioned This In A Recent Post)

Why don't you take Spiro anymore? (You mentioned this in a recent post)

My T is sufficiently suppressed without it. Estrogen and Testosterone inhibit each other through indirect pathways- both signal the hypothalamus and pituitary, which in turn signal the testes/ovaries to produce more or less of their hormone. Unfortunately, T is a more potent suppressor of E than vice versa, so a blocker is needed to drop T levels at first (usually), which then lets E get high. Once E is high enough, then it can suppress T production on its own. For me specifically, I've never had a problem suppressing T, especially later into HRT when my E was getting somewhat higher. Even after quitting spiro, my T has never gotten above 20 ng/dL, and is mostly around 15 ng/dL, which is on the low side of normal even for cis women. AA in general are theoretically unnecessary once E is high enough to suppress T on their own, but this varies strongly dependent on the individual hormone metabolism from person to person. Fun fact, this is also why masculinizing hormone therapy is way simpler than feminizing hormone therapy- T is potent enough to inhibit E right off the bat without extra help.

Personal consideration to add here: I'm quickly learning that I'm a rapid metabolizer, along with about 20-30% of the human population. Essentially this means that most medication has shorter effect periods on me, and I believe it also has had an effect on how effectively my T got suppressed. My T levels were low almost immediately when I started HRT, and I started with spiro. But, the price I had to pay is that its taken forever for my E to go up. With that in mind, I realized that for me specifically, I didn't have to worry about my T going back up if my E wasn't high enough yet.

The above are about why I felt spiro was unnecessary, but why not take it just in case? Simple- side effects. I was having very noticeable diuretic side effects to the point where it interfered with my usual routines, so I tried to quit as soon as I could. Once I quit, a brain fog that I didn't even notice was there, lifted. I was having a lot of issues that I now realize were due to low sodium- my energetics were fucked, my vision was getting hazy when I stood up, and my heart pounded in situations it didn't need to. When I quit spiro, these stopped almost immediately, and I realized that these were side effects that I hadn't even registered as side effects.

These were considerations I made based on my own personal situation, but hopefully it helps. I haven't been on an AA since February or so. I actually just got a levels test back (spreadsheet update pending) and it confirms that my T has been within cis female ranges since early October, and on the low side of cis female ranges since early November.

In my personal opinion, AAs should be used more conservatively than it currently is, but are still necessary for HRT. My ideal HRT based on papers I've seen, personal experience, and conversations with my provider is essentially: brief period of E monotherapy-> E+AA until T is suppressed and E levels are high -> E monotherapy -> additional considerations (like prog). This is not coming from a medical perspective, though, just an anecdotal one.

More Posts from Zephiris and Others

1 year ago
@gaugevectormoron This Was Just Too Good To Leave In The Tags. Also Yay It Turns Out I’m Not Alone

@gaugevectormoron this was just too good to leave in the tags. Also yay it turns out I’m not alone in this specific oddity of mine :D

I have a question: has anyone else tried using their boobs’ nipples to scroll on a touchscreen or is this an insane person activity I have just attempted?

I tried to google it but it’s a pretty unsearchable query.

1 year ago

My guess would be that the compiler is not added to your PATH environment variable or you need to restart your computer. I’m not sure which OS you’re on, but if you follow the instructions on this page in the “install a compiler” section then that should help you properly configure your PATH environment variable.

hi sorry if this is a dumb question but I'm just starting to learn to code and I can't figure out how to set up visual studio code for c++. I've installed the extension and a compiler but still it doesn't work. Maybe you or one of your followers could help me out?

Hiya 💗 Yeah I don’t have any experience in C++ so if someone could help out here thank you!

1 year ago
Reblog To Kill It Faster

Reblog to kill it faster

11 months ago

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1 year ago

It’s really funny to me how this post simultaneously appeals to queer geeks and programming geeks (and those that are both) which is exactly my target demographic!! Also woooo first post to get attention from people that I didn’t know existed! I’m stocking all yall’s profiles — you have been warned

Here I was trying to search for cool people on Tumblr when instead I can just honeypost and let the cool people slowly reveal themselves to me via likes/reblogs

Java is a trash language that should burn in the parts of hell where hitler is

Rust on the other hand is a bratty lil language that should burn in the parts of hell where queers party

8 months ago

Rule

Rule

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6 months ago

And now for something completely different.

Photograph of a colourful, somewhat roughly-made clay teapot decorated in splotches of red, yellow and blue. It has four different spouts of various lengths pointing in different directions.

This is the ADHD Teapot. I made it in a ceramics class a few years ago. I use it to explain executive dysfunction to people who haven’t come across the term before (and those who think of ADHD mostly as Hyperactive EightYear Old Boy Syndrome).

So, most people’s brains are like a regular shaped teapot with a single spout. Let’s say that your time, energy, focus etc is the liquid you have in the teapot. Your executive function is the spout, that directs the tea into the specific cup you want to fill-aka the task that you’re meant to be doing. Spills happen occasionally, but generally most of the tea goes in the right cup.

If you have executive dysfunction, you have multiple spouts going in different directions. You can try pointing one of them at your chosen cup and you will probably get some liquid in there, perhaps you will even fill it right up (finish the task). But meanwhile, tea is also pouring out of several other places and not going where you want it. If you have another container nearby, perhaps some of it will end up in there. But quite a lot of it is going to end up on the floor and accomplish nothing.

And at the end of the day you’ll have filled one or two cups ( or sometimes not even one) compared to the five or six that somebody with the same sized teapot (but only one spout) has filled, and everyone wonders why you’re so bad at getting tea poured, and why you make such a mess in the process.

One day I’d like to spend more time learning pottery and create a really technically good fucked up little adhd teapot. But that’s a long way off since i currently live in the outback and the nearest pottery workshop is some 400km away. But I figure that for now, it might be a useful or interesting metaphor to somebody even in its rough draft form.

This post is the cup I filled instead of cleaning my house btw.


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1 year ago

I have a question: has anyone else tried using their boobs’ nipples to scroll on a touchscreen or is this an insane person activity I have just attempted?

I tried to google it but it’s a pretty unsearchable query.


Tags
1 year ago

oh shit, it's 3/21/23, 32123, palindrome day

1 year ago

All fancy smancy generative ai models know how to do is parrot what they’ve been exposed to.

A parrot can shout words that kind of make sense given context but a parrot doesn’t really understand the gravity of what it’s saying. All the parrot knows is that when it says something in response to certain phrases it usually gets rewarded with attention/food.

What a parrot says is sometimes kinda sorta correct/sometimes fits the conversation of humans around it eerily well but the parrot doesn’t always perfectly read the room and might curse around a child for instance if it usually curses around its adult owners without facing any punishment. Since the parrot doesn’t understand the complexities of how we don’t curse around young people due to societal norms, the parrot might mess that up/handle the situation of being around a child incorrectly.

Similarly AI lacks understanding of what it’s saying/creating. All it knows is that when it arranged pixels or words in a certain way after being given some input it usually gets rewarded/gets to survive and so continues to get the sequence of words/pixels following a prompt correct enough to imitate people convincingly (or that poorly performing version of itself gets replaced with another version of itself which is more convincing).

I argue that a key aspect of consciousness is understanding the gravity and context of what you are saying — having a reason that you’re saying or doing what you are doing more than “I get rewarded when I say/do this.” Yes AI can parrot an explanation of its thought process (eli5 prompting etc) but it’s just mimicking how people explain their thought process. It’s surface level remixing of human expression without understanding the deeper context of what it’s doing.

I do have some untested ideas as to why its understanding is only surface level but this is pure hypothesis on my part. In essence I believe humans are really good at extrapolating across scales of knowledge. We can understand some topics in great depth while understanding others similarly on a surface level and go anywhere in between those extremes. I hypothesize we are good at that because our brains have fractal structure to them that allows us to have different levels of understanding and look at some stuff at a very microscopic level while still considering the bigger picture and while fitting that microscopic knowledge into our larger zoomed out understanding.

I know that neural networks aren’t fractal (self-similar across various scales) and can’t be by design of how they learn/how data is passed through them. I hypothesize that makes them only understand the scale at which they were trained. For LLM’s/GAN’s of today that usually means a high level overview of a lot of various fields without really knowing the finer grain intricacies all that well (see how LLM’s make up believable sounding but completely fabricated quotes for long writing or how GAN’s mess up hands and text once you zoom in a little bit.

There is definitely more research I want to do into understanding AI and more generally how networks which approximate fractals relate to intellegence/other stuff like quantum physics, sociology, astrophysics, psychology, neuroscience, how math breaks sometimes etc.

That fractal stuff aside, this mental model of generative AI being glorified parrots has helped me understand how AI can seem correct on first glance/zoomed out yet completely fumble on the details. My hope is that this can help others understand AI’s limits better and therefore avoid putting too much trust into to where AI starts to have the opportunity to mess up serious stuff.

Think of the parrot cursing around children without understanding what it’s doing or why it’s wrong to say those words around that particular audience.

In conclusion, I want us to awkwardly and endearingly laugh at the AIs which mimic the squaks of humans rather than take what it says as gospel or as truth.


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zephiris - another transfem programmer
another transfem programmer

20, They/ThemYes I have the socks and yes I often program in rust while wearing them. My main website: https://zephiris.me

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