In a new study, scientists with the University of Florida have found that a combination of silver nanoparticles and antibiotics is effective against antibiotic-resistant bacteria.
The researchers hope to turn this discovery into viable treatment for some types of antibiotic-resistant infections. Antibiotic-resistant infections kill more than a million people globally each year.
For centuries, silver has been known to have antimicrobial properties. However, silver nanoparticles—microscopic spheres of silver small enough to operate at the cellular level—represent a new frontier in using the precious metal to fight bacteria.
In this study, the research team tested whether commercially available silver nanoparticles boost the power of antibiotics and enable these drugs to counter the very bacteria that have evolved to withstand them.
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just learned that humans might have evolved smaller pupils and irises/more whites of our eyes so that it's easier for other humans to tell where we're looking as a way of communicating sudden threats. and now i'm thinking of every time i have been frantically giving my friend a Look to get out of an uncomfortable situation (or been on the receiving end). still using it to communicate sudden threats only this time his name is kyle
VACCINATE YA KIDS FFS
The bacteria wars are coming. Researchers at Tel Aviv University have pitted “good” bacteria against “bad” bacteria and the good guys, it appears, are winning.
If the system can be scaled, this new approach could potentially replace antibiotics, which are increasingly struggling against antibiotic-resistant “superbugs.” For the TAU study, the researchers used a toxin injection system known as a “Type 6 Secretion System.” It’s usually deployed by pathogenic (“bad”) bacteria. They introduced the system into a “friendly” bacterium, Vibrio natriegens, which is not harmful to humans. The researchers described their technology as similar to a microscopic poison arrow shot from a good bacterium to eliminate a bad bacterium under specific conditions. “The system that we built allows us to engineer ‘good’ bacteria that can recognize pathogenic bacteria, attack them with toxins, and neutralize them,” explains Dr. Dor Salomon, who co-led the study. “We know how to change and control every component in the system and create a bacterium that neutralizes different strains of bacteria. This is proof of feasibility, showing that we have the knowledge and ability to create bacteria that take advantage of this killing system and may serve as antibiotic treatments. ”The current bacteria prototype is best suited for bugs that occur naturally in saltwater. This is a growing concern, as fish and seafood constitute a major food source in many regions of the world. “Their productivity is severely impaired as a result of bacteria-borne diseases,” Solomon notes, “and since we want to avoid pouring antibiotics into aquaculture farms, a biological solution such as the one we have developed is an effective alternative.” The system will eventually be adapted to treat pathogenic bacteria in humans, farm animals and plants. Tel Aviv University has filed a patent application through Ramot, the university’s technology-transfer company. In addition to Solomon, Dr. Biswanath Jana and Kinga Kappel of the department of clinical microbiology and immunology at TAU’s Sackler Faculty of Medicine participated in the research. The results were published this month in the scientific journal EMBO Reports.
Therocephalians were a group of synapsids very closely related to – or possibly even ancestral to – the lineage leading to modern mammals. They were a diverse and successful group of carnivores during the latter half of the Permian, but suffered massively during the "Great Dying" mass extinction, with only a handful of representatives making it a few million years into the Triassic.
Tetracynodon darti was one of these rare Triassic therocephalian survivors, living in what is now South Africa around 251 million years ago. Only about 25cm long (~10"), it had slender limbs and strong claws that suggest it was a scratch-digger. Its long snout was lined with pointed teeth, and it was probably an active predator hunting by snapping its jaws at fast-moving prey like insects and smaller vertebrates.
Its combination of small size, burrow-digging habits, and unspecialized diet may be the reason it scraped through the Great Dying when most of its relatives didn't – but unfortunately it seems to have been a "dead clade walking", disappearing only a short way into early Triassic deposits.
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References:
Fontanarrosa, Gabriela, et al. "The manus of Tetracynodon (Therapsida: Therocephalia) provides evidence for survival strategies following the Permo-Triassic extinction." Journal of Vertebrate Paleontology 38.4 (2018): 1-13. https://doi.org/10.1080/02724634.2018.1491404
Sigurdsen, Trond, et al. "Reassessment of the morphology and paleobiology of the therocephalian Tetracynodon darti (Therapsida), and the phylogenetic relationships of Baurioidea." Journal of Vertebrate Paleontology 32.5 (2012): 1113-1134. https://www.researchgate.net/publication/254315180_Reassessment_of_the_Morphology_and_Paleobiology_of_the_Therocephalian_Tetracynodon_Darti_Therapsida_And_The_Phylogenetic_Relationships_of_Baurioidea
Wikipedia contributors. “Tetracynodon” Wikipedia, 21 Aug. 2024, https://en.wikipedia.org/wiki/Tetracynodon
Wikipedia contributors. “Therocephalia” Wikipedia, 01 Oct. 2024, https://en.wikipedia.org/wiki/Therocephalia
Stop the ban on blood donation of gay men
Fun fact: my dad, after being a surgeon for 25 years, no longer has fingerprints. The sponge he uses to wash his hands several times a day is so harsh that it’s rubbed off his fingerprints throughout the years. Sometimes he can’t get into our building because the biometric uses a fingerprint scanner 😭
Stop the ban on blood donation of gay men
is there a name for this
So I read the article, and this is super cool. Basically what happened is that they let a drop of butyl alcohol out from a syringe onto the surface of another liquid, and it just... hung out there? For a very significant amount of time, too. In the past, this type of "droplet levitation" has only lasted a few milliseconds max, but this droplet was staying levitated without any external forces applied for tens of minutes.
The reason this happens is because of Solutocapilllary convection, which as far as I can tell essentially boosts the surface tension of that one spot in the underlying liquid using vapor molecules, so that the butyl alcohol molecule can't sink in.
Also, the reason why I specified that the reason this was cool is because it was done without external forces is that APPARENTLY we've been able to levitate things using sound waves since like... the 1930s. And it makes sense that you can do that, in principle, but it still looks absolutely wild to see.